- Alzheimer's disease
- Brain signalling
- Cancer (breast)
- Cancer (lung)
- Cancer (skin)
- Cancer (brain)
- Cancer (general)
- Cystic fibrosis
- Diet and health
- Drug clearance
- Drug metabolism
- Foetal studies
- Heart disease
- Huntington's disease
- Intestinal infections
- Kidney failure
- Liver disease
- Lung diseases
- Multiple sclerosis
- Pain studies
- Parkinson's disease
- Sleeping sickness
- Vascular disorders
- Whooping cough
- Wound healing
Cancer gene therapies
2000 – 2003 Glasgow University, Dr R Mairs & Dr M Boyd
Exploration in human tumour spheroids (three-dimensional cell cultures) of the potential for gene therapy to improve cancer radiation treatments, as an alternative to studies in rats or mice with implanted tumours.
Antibodies and cancer diagnosis
1997 – 2000 Newcastle University, Dr E Routledge & Dr B Angus
Investigation of in vitro production of antibodies for use in diagnosis and assessment of human breast and skin cancers, to replace standard production methods in mice.
1984 Nottingham University, Dr S Brown
Cell culture investigation of genetic susceptibility to chemically-caused cancers to replace the need for experimentation on mice and rats.
Cell-based cancer research
1982 Glasgow University, Dr I Freshney
Investigation of invasiveness of human cancer cells from lung biopsies, as an alternative to animals, such as mice and guinea pigs, with implanted tumours.
Improving childhood cancer therapies
1996 – 1998 Glasgow University, Dr T Wheldon
Improvement of treatment strategies for targeted radiotherapy of neuroblastoma and non-Hodgkins lymphoma by mathematical modelling, to by-pass animal tests on mice with implanted tumours.
Vitamin C and gastric cancer
1990 – 1993 Leeds University, Dr C Schorah
Use of gastric biopsy samples from volunteers to investigate the role of vitamin C in the prevention of stomach cancer, as an alternative to experiments on guinea pigs, rats, birds and monkeys.
Cancer drugs in human cells
1987 Cambridge University, Dr P Smith & Prof NM Bleehen
Evaluation of anti-cancer drugs by screening samples of human cells for DNA damage, as an alternative to animal studies in cats and dogs.
1980 Edinburgh University, RJ Prescott
Computerised data storage and processing of pooled clinical information, to improve lymphoma treatments without resorting to animal experiments using mice, rats and fish.